CBD softgels vs Capsules and side effects

What is a CBD softgel?

A CBD softgel contains hemp extracted from CO2 with an oil containing CBD and packaged in a soft, anti-penetration and soluble coating.

What is a CBD capsule?

A CBD capsule contains raw and ground cannabis powder in a hard, soluble container with 2 pieces.  CBD softgels vs Capsules 

Possible Side Effects

Given the benefits of taking CBD, clinical research has shown that taking CBD softgels and capsules can cause side effects. But its severity and weakness vary from person to person.

Common symptoms include:

  • Anxiety
  • Changes in appetite
  • Changes in mood
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Nausea
  • Vomiting

Taking cbd softgel may also cause an increase in liver enzymes. People with liver disease should use it with caution.

You should avoid driving or using heavy machinery while taking CBD softgels and capsules, especially when starting treatment.


CBD can also interfere with certain medications, including some medications used to treat epilepsy. By interfering with CYP450, CBD may increase the toxicity or reduce the effectiveness of these drugs.

Common Side Effects of CBD softgels and capsules

The most common side effects of CBD softgels and capsules include drowsiness, gastrointestinal problems, dry mouth, loss of appetite, nausea, and interactions with other medications.


Taking high doses of CBD softgels and capsules can lower blood pressure in people and increase the risk of a sudden drop in blood pressure while standing.

As a result, one of the side effects is dizziness.

People with low blood pressure are at greater risk and should be careful about taking CBD and never try it without talking to their doctor.

Digestive Issues

Both CBD softgels and capsules supplement have been reported to cause digestive problems such as:

  • Nausea and vomiting
  • Diarrhea
  • Increased or reduced appetite
  • Weight loss or gain

These effects are most likely caused by the irritating effects of other substances (eg, carrier oils) on the intestines.

Be sure to tell your doctor if you experience digestive problems with CBD softgels and capsules. He may recommend reducing the dose of the drug.

Dry Mouth

Approximately 12% of the 1,500 people who responded to the CBD survey said that whether they used CBD for recreational or medical purposes, they suffered from dry mouth, making it the most common side effect.

Stimulation of CB1 and CB2 receptors in the salivary glands reduces salivation, which causes dry mouth. The famous combination of THC cannabis directly activates these receptors. In fact, CBD increases the level of activator that is naturally produced in the body – cannabinoid anandamide.

Can Interact With Other Medications

Another side effect is that CBD may interfere with other medications you are taking. Be sure to consult your doctor in this case.


In some cases, nausea may occur for those taking CBD softgels and capsules supplements. It depends on how sensitive the person is to CBD as well as the dose.

Drowsiness and Fatigue

One of the side effects seen in early clinical trials is that people who take CBD supplements often feel drowsy and tired.

The effect of CBD on sleep seems to be twofold: high doses may increase sleep time, lower doses may cause wakefulness. In addition, the level of endocannabinoid receptors depends on the circadian rhythm.


In contrast, very high doses may even cause anxiety and irritability. This was the case in 7-9% of children in 2 clinical trials using CBD for seizures and autism

CBD boosts the naturally-produced cannabinoid anandamide.Moderate levels of anandamide activate CB1 receptors and reduce anxiety, but large amounts may worsen by binding to TRPV1. CBD also activates this receptor directly, further contributing to the potential effects of anxiety stimuli.

Kidney Health

According to a recent study, THC may impair kidney health and increase urination by activating CB1 receptors. However, CBD may indirectly activate anandamides by increasing levels in the body.

Risk Populations

It changes the level of two drug carriers in placental cells. This suggests that taking CBD softgels and capsules during pregnancy may increase the fetus’ exposure to any medication the mother is taking. Pregnant women should avoid CBD supplements in any case. 

It is also very dangerous to take a CBD supplement containing THC during pregnancy and lactation, because THC reduces fetal growth and can cause brain development abnormalities in infants. How long does wax pen stay in your urine

Can CBD promote weight loss?

CBD has been purported to improve other aspects of health, including weight loss. A few of its potential effects are outlined below.

May boost metabolism and reduce food intake

Preliminary research suggests that CBD may reduce food intake and boost metabolism, which could promote weight loss.

For example, animal studies indicate that CBD affects weight by interacting with CB1 and CB2 receptors in lymphoid tissue and the brain. These receptors are thought to play important roles in metabolism and food intake.

In a two-week study, rats were injected with CBD daily at doses of 1.1 and 2.3 mg per pound of body weight (2.5 and 5 mg per kg). Both doses produced significant reductions in body weight, with the higher dose having the most pronounced effect.

It’s important to note that CBD was injected, not given orally.

In another rat study, CBD led to a significant reduction in food intake compared to other cannabinoids, including cannabigerol and cannabinol.

While such results are promising, not enough human studies support these findings, and more research is needed.

May promote ‘browning’ of fat cells

Two types of fat — white and brown — exist in your body.

White fat is the predominant form, responsible for storing and supplying energy while insulating and cushioning your organs.

It’s also the type of fat most associated with chronic illnesses — such as diabetes and heart disease — when accumulated in excess.

On the other hand, brown fat is responsible for generating heat by burning calories. Individuals with a healthy weight tend to have more brown fat than overweight people.

You can convert white fat to brown by exercising, getting adequate sleep, and exposing yourself to cold temperatures.

Interestingly, research shows that CBD may aid this process.

A test-tube study found that CBD led to “browning” in white fat cells and enhanced the expression of specific genes and proteins that promote brown fat.

However, human research is needed to confirm these effects.

Marijuana use is associated with lower body weight

Although marijuana use is commonly associated with increased food intake, those who use marijuana products tend to weigh less than those who don’t.

For example, a review in over 50,000 people noted an obesity rate of 14–17% among those who used cannabis at least 3 days per week, compared to 22–25% for those reporting no marijuana use in the past 12 months.

As CBD is prevalent in marijuana, it’s likely involved in this relationship — although it’s unclear how.


Back to top